A simple, accurate, validated and reproducible UV-spectrophotometric method has been developed for the simultaneous estimation of Levocetrizine Dihydrochloride (LCT) and Ambroxol Hydrochloride (AMB) in both bulk and tablet formulation. Multicomponent mode was used for the estimation of Levocetrizine Dihydrochloride and Ambroxol Hydrochloride in combined tablet formulation. The λmax was found to be 231 nm for Levocetrizine Dihydrochloride and 245 nm for Ambroxol Hydrochloride in their solution in 0.1N HCl solution. Beer’s law was obeyed in the concentration range of 10-50µg/ml for Levocetrizine Dihydrochloride and 10-90µg/ml for Ambroxol Hydrochloride. Mean recovery of 100.197% and 99.95% for Levocetrizine Dihydrochloride and Ambroxol Hydrochloride respectively signifies the accuracy of the method. Commercial tablets containing 5mg and 75mg of Levocetrizine Dihydrochloride and Ambroxol Hydrochloride (ALCOCE-XL and LEVOSTAR-AM) were analyzed by the proposed method and the results were found to be within the claimed limits. The present work describes a simple, accurate, reproducible, rapid and economic method for simultaneous estimation of LCT and AMB in tablet formulation.
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